Cat, Dog, Horse
Isoflurane is administered by inhalation. Absorption takes place across the alveolar exchange membranes at a rate determined by the rate and depth of respiration, by the cardiac output and by the solubility of isoflurane in the blood.
Isoflurane has a low blood/gas partition coefficient (i.e. it is poorly soluble) and equilibration between alveolar gas and the circulation is therefore rapid, in the order of 30 minutes.
Distribution of isoflurane is dependent on cardiac output and the partition coefficients of the various tissues. Again these tend to be low so distribution is rapid.